Strategies for Achieving Oxygen Tolerance in Reversible Addition–Fragmentation Chain Transfer Polymerization

Abstract Reversible addition–fragmentation chain transfer polymerization (RAFT) is a popular method for the synthesis of well‐defined macromolecules, but its sensitivity to oxygen major limitation many industrial applications. Recent research has focused on developing strategies confer tolerance onto RAFT polymerization, eliminating need deoxygenation steps and allowing simpler reaction conditions. This minireview highlights several promising approaches achieve in including enzyme‐mediated, alkylborane‐initiated, photomediated methods. The potential applications oxygen‐tolerant are also discussed, demonstrating promise significant advances large‐scale polymer synthesis.